@grandmar I've been seeing a therapist. It hasn't done much good. It may or may not be the Seroquel. But I think that's the problem. It seem like the effexor leveled off and started working and then the Seroquel kicked in and I started getting headaches and VERY irritable. I read up on Seroquel and it said it can cause irritably and headaches. So I'm not sure what to think. But I get very irritated and don't feel like myself. It's been a heck of a ride.