@cabgreenbay I have stayed at Aspens Suites when I had surgery at Mayo Mary Brigh Hospital and is it literally just across the street. You just cross at a stoplight with a crosswalk and enter a side entrance at the hospital (Tower Entrance). Hotels wit close access are more expensive. If you are will to ride a shuttle or have a car with you, you can stay further out. I like Candlewood Suites because it has a full kitchen, also some underground parking. I have food issues, so I have trouble finding anything at a provided hotel breakfast that I can eat. Candlewood Suites also has some kitchen equipment to lend like a crock pot.

@cabgreenbay

@jenniferhunter provided some great information.
In addition, may want to check out this site about any construction affecting arriving at Mayo.
https://www.mayoclinic.org/rochester-construction
When are your appointments?

I have been to Mayo many times for surgery and visits. Initially when I didn’t know my way around, I stayed at the Marriott or the Kahler that are connected to the Gonda building and Methodist hospital. Since then, I always stay at the Fairfield Marriott and suites on 16th St. It is a wonderful place. The management is great. They have a breakfast and it is now my go to destination to stay. They do have a shuttle but often times I will just drive from there to the Damon or Graham ramp and it brings you right into the buildings at the subway level underground if you were going a lot, you can stop at the valet once you were inside and buy a five or 10 day parking ticket which makes parking cheaper. Good luck to you!