I think I've been off these drugs for almost a year, & my knees still hurt, but I do have mild arthritis. For some reason, one knee had a torn meniscus, for no reason that I can think of. It was repaired, but the other knee always hurt a little. I recently stepped up my walking routine; it started hurting like hell, crippling. The Ortho found nothing wrong except, again, mild arthritis. He gave me a cortizone shot, & it has helped a great deal. My knees were just fine until I started the armatose inhibitors. Thank you for posting. I was wondering if others reacted similarly.