I hope the Tagrisso works for you. I had to stop as it caused pneumonitis in all 5 lobes. Thankfully my last scan shows me in complete remission. Praying it stays that way. Good luck

@camorton47 , welcome to Mayo Connect, and thanks for sharing your story. Your body has been through a lot. Could the pain, shortness of breath, and cough still be related to the surgical healing? Or does your doctor think it's the Tagrisso? It's probably hard to know at this point.
I hope that you are able to tolerate the Tagrisso. As others have noted here, if you continue to have problems once you start the med again, you may want to discuss a reduced dose with your oncologist.

@camorton47, welcome. I started like you: two nodes in the upper right lobe. But Tagrisso was not the standard of care in the first round in 2018, so I had a lobectomy followed by chemo (Carboplatin/Alimta) and radiation. After my cancer metastasized to my brain, I started 80 mg of Tagrisso daily. That was over 4 years ago. After the lobectomy in 2018, I've never had a recurrence below my neck.

Typical Tagrisso side effects are diarrhea (everybody), skin rash, and nail splitting/chipping. After that, there are some more unusual ones. I've never had the skin rash until recently, but that might be due to another treatment I've had. I take 20 mg Biotin daily to correct the annoying nail splitting. The diarrhea faded away after a few months. Now, I take Metamucil every morning to stay regular!

Tagrisso has been a godsend for us with the EGFR mutation. I know a 7-year survivor, and counting, and one of my doctors has a patient who's been on it for 11 years.

I'd be surprised if the pain, breathlessness, and cough were due to Tagrisso, so please let us know if your oncologist becomes convinced that's happening. Otherwise, I hope you recover soon and can restart Tag.