Just a few observations:

It would be unusual for "loss of use of legs" (if you mean he is paralyzed below the waist) to be due to sacral fractures. The nerves affecting motor function of the lower extremities exit above the sacrum. Does he have any fractures in the spine elsewhere? Sacral fractures can be difficult to heal but can be treated by an Interventional Radiologist doing a procedure called sacroplasty. Using CT guidance, a needle is placed into the fracture and cement is injected to stabilize the fracture. This is performed for unrelenting, persistent pain for fractures that won't heal after a few months.

The whole purpose of any ADT medication (Orgovyx/Lupron) is to severely lower the testosterone level. How long the T stays depressed is mainly dependent on: 1) patient age, 2) length of time on ADT and 3) the T level prior to beginning treatment. Older men (>70) may never regain normal (>250-300) levels of T. Once T level becomes normal, most men regain libido. It may take time, exercise etc to build bone mass if the T levels return to normal. I do not know about the anemia.

Reportedly, men tend to regain T levels faster after discontinuation of Orgovyx than Lupron.