Yes I always take prednisone with food- buried in a spoon of yogurt! It’s the only way for me. I kept it beside my bed. Taking it at breakfast was too late for me- too much pain getting out of bed. I’d rather get the pred working as I slept. It has never disturbed my sleep. Plus I’m up 2-3 times anyway for bathroom. Family trait. I’m at 3 now and ready to taper to 2.5 in two weeks. Evening dose now works best. I found it best to adjust habits as PMR evolved. What works at one stage, may not be best as disease progresses. I learned that tactic early on from this chat room. As I’ve learned so much. Good luck.