My Rheumatologist recommended Acthar Gel. It stimulates your adrenal gland to produce natural cortisone when it senses inflammation. I hated prednisone due to side effects. I've been on a once a week shot for 6 weeks now and I am noticing a big improvement. My flares are milder and my pain level has dropped by 3-4 points. I'm nauseated the day I inject but no other side effects. You might want to discuss with your Dr❣️