@bayhorse, I'm on transdermal estradiol. I was on .025 for the past 6 years but over the last several months, increased my dose to .05 as I was getting nervous over a reduction in density on a few vertebrae even though my overall T-score remained the same at 2.9. I don't understand that and my endo just blew it off saying it's an algorithm. I've used several brands of estradiol and find that I like Sandoz the best as it generally adheres better than the others and I find I have less itching from the adhesive. I was on 100 mg micronized progesterone until I increased my estradiol. They then increased my progesterone to 200mg.