Recently diagnosed: Treatment options for early stage prostate cancer?
Im 57 and was diagnosed with prostate cancer on 4/21/23. Following a 3t mri which revealed a pirads 5 leasion I had a targeted mri fusion guided biopsy. The pathology report revealed adenocarcinoma in 2 of 14 cores. Gleason 7 (3+4), grade group 2, 30% involved. Chronic inflammation was noted as well in areas around the cancer. My PSA started in 2109 at 1.8 and went to 2.1, 3.57, 5.91 and 6.7 a couple of months after the 5.91 and before the biopsy. My PSA density is 0.15. My urologist recommended surgery and a consult with a radiation oncologist obviously suggested radiation therapy but states active surveillance might be appropriate if the second opinion on my slides didn’t change. Any thoughts?
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I had my biopsy on January 24. Gleason score 7 (3+4). PSA 10.5
I had my "nuclear medicine bone scan + SPECT + CT X2 Panel" last Thursday. No scintigraphic evidence of (rules out) osseous metastatic disease from prostate. My CT scan for the pelvis and stomach is on Friday, Feb 28. If also negative for cancer spread, I'm thinking of RP. I would like to compare notes with similar cases as mine, what worked for them: surgery or radiation treatment. Thanks.
In my case, my PSA rose from 7.9 in late October 2024 to 10.5 in late January 2025. My primary care provider referred me to a urologist at Mackenzie Health Richmond Hill, Ontario who took 12 (or 14) specimens from my prostate on Jan 24. Finding: Gleason score 7 (3 + 4) on three cores. The Feb 14 "Nuclear Medicine whole body bone scan + SPECT +CT X2 Panel" found "No scintigraphic evidence of osseous metastatic disease from prostate." The CT scan of my pelvis and abdomen is scheduled for Feb 28, after which I will have my initial consultation with the oncologist. I will have the chance to choose between radiation or "surgery if both the bone scan and CT scan are both negative (that I hope they are)." Any one with similar situation in the past as mine -- PSA 10.5, Gleason 7, PC not spread, kindly comment which treatment path you chose, why? And the outcome. Thanks.
@virgil
Ask your oncologist about Decipher test. It uses the same biopsies (if qualify) to determine a more precise of your risk. This will help you and your oncologist a more precise options for treatments.
Example: My Gleason was 3+4=7 and intermediate risk. Oncologist recommendation was radiation and hormone treatment but wanted to do a Decipher test. It was done and came back low risk not intermediate risk. This changed my treatment recommendations (from two different medical facilities consultatsions) to just radiation.
I chose proton radiation low dose 30 rounds done at UFHPTI. I had mild side affects that slowly went away after treatments ended and I am back to normal 1.5 years from treatments.
Outcome. I was at 3.75 PSA when had treatments. Had gone up every 3 months for about 3 years from .75 to 3.75. My PSA is now .22 as of December 2024. My R/O goal was to have it below 1. So the outcome for me is positive results from the treatment. I have PSA done every 3 months and meet with R/O every six months. I see my PCP every 3 months.
Please consider the Decipher. It really changed me treatment options. Also if you have any doubt of your diagnosis or treatment get a second opinion.
I did not see you had the PSMA test done. I am not famiiar with the tests you mentioned using CT scans. The tests done on my at Mayo Jacksonville and UFHPTI were: MRI with contrast, Biopsies using MRI/Fusion, bone scan, Decipher, PSMA.
Thank you.
I will ask if Decipher test is done in Ontario.
(It seems to me that different jurisdictions have different tests, and different hospitals provide different treatments, e.g., one may do open surgery, one will do radiation, another will do robot-assisted prostatectomy.)
My urologist referred me to a hospital that does robot-assisted. But I will see what the oncologist says.