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Persistent Positive ANA, Now DFS70 – Does This Indicate Recovery?

Autoimmune Diseases | Last Active: Mar 6 4:38am | Replies (12)
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@celia16

What does speckled mean?

Also, have you heard of an ANA result that says Abnormal. Not negative or positive?

I’m recalling sime things in my tests. I haven’t looked at them in a couple of months. Rheumatologist thinks I’m not suffering from autoimmune disorder. I mean, I have type 1 diabetes, psoriasis and hypothyroidism, but besides those things,

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Replies to "What does speckled mean? Also, have you heard of an ANA result that says Abnormal. Not..."
seniormed | @seniormed | Feb 23 4:25pm

DM type one, hypothyroidism and psoriasis can all be
considered autoimmune diseases.
A speckled pattern refers to the appearance of fluorescent
antibody under microscopic view of specially prepared cells
in a lab test for systemic autoimmune diseases. The pattern can be seen in normal people that show no symptoms as well. Diffuse Fine Speckled (DFS) 70 is a large protein antibody molecule . 70 is the “weight”measure of the molecule in biology terms.
It is thought it may be a good sign that our AntiNuclear
Antibodies -ANAs are not the type causing disease if
DFS antibodies are measurable as well in our battery of
tests.

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artemis1886 | @artemis1886 | Feb 24 8:05pm

I have had a speckled ANA positive
A speckled ANA pattern indicates the presence of antibodies that target specific proteins in the nucleus of cells. This pattern is often associated with autoimmune diseases such as:
Systemic lupus erythematosus (SLE), Sjögren's syndrome, Scleroderma, and Rheumatoid arthritis
Have you had the gland biopsy by an ENT and the test by the eye doctor for Sjogrens?

DFS70 antibodies are a subgroup of ANA that appear as a fine, dense speckled pattern under a microscope
They are found in 10% of healthy people, but only a small number of people with autoimmune rheumatic disease
They are a useful marker to help distinguish people with positive ANA who don't develop systemic autoimmune disease

Positive Ana still means your autoimmune system is messed up. Mines always high.

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