This is all out there at the fringes of my very limited knowledge base I was a student when we didn't even think of decoding the human genome...Immunology was a science fiction type of new frontier. I learn what I can from reading but nything seriously medical is mostly incomprehensible. My rheum is very good at explaining anything I ask but my education on the basics of immunology, the inflammation process, and biologic drugs is laughably inadequate. I read, reflect briefly and stay focused on my mindfulness program, eat healthy, exercise, and do needlework and read. I read less and less on PMR because it doesn't make a difference in my daily life any more.
So while I have seen a few things addressing your questions, I don't want to pass them along . You're on the right track. My answers would be laughably vague.