I've had lots of endometrial biopsies in the past and my recommendation is to take up to 4 Advil at least an hour ahead and ask for a heating or warming pad to place on your abdomen during the procedure. It really helped me during the last one. Definitely not a fun procedure but it is pretty quick and only really hurts while they're in there. It's important to get it done. My last one showed endometrial adenocarcinoma and I had a full hysterectomy 5 weeks ago. Don't delay any investigation of unusual symptoms! Best wishes and hugs to you