We all are using slightly different HRT. I am using compounded estradiol and testosterone and 100 promethium. I use transdermal. I feel so much better. Hormones facilitate muscle and bone growth. I am on Tymlos for two years. I had one reclast infusion and will have 2 more ( maybe it is 3, I forget) annually and then I am done for life I was told. I am 68 currently. I will stay on the BHRT as long as all tests look good. All of these things come with some risks and my family history of cancer and heart disease require periodic observation. I hope that helps.