I have been on Eliquis for 1 year and 3 months for DVT, PEs, and a saddle embolus. I have experienced fatigue and muscle weakness, but I did not associate it with Eliquis. Approximately one month ago, my dose was decreased for maintenance, and I begin to experience severe pain in my hips and legs which impaired my mobility. This occurs every morning when I get up and when I have sat too long. The pain is relieved with Acetaminophen after approximately 30 minutes and I am able to ambulate without any problems. However, I am taking Acetaminophen every 6 hours to combat the pain. I recently had an x-ray done and was told that no problem was seen. These symptoms are not listed as a side effect for Eliquis, but that does not mean it is not a side effect. I am a registered nurse with 43 years of nursing experience, and 34 years was in critical care. I personally feel this needs to be investigated to determine if there is a correlation of these symptoms with Eliquis. It will never be determined a side effect if some research is not done to rule it in or out. I am happy to discover this blog. This blog is connected to the Mayo Clinic, and maybe it will draw attention to the research department so that the issues will be looked at closer. If anyone else has these problems, please blog about it so that it can at least be looked at.