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Risedronate Sodium 150mg

Osteoporosis & Bone Health | Last Active: Mar 4 11:58am | Replies (33)

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@mayblin

Hi @awfultruth i'm interested in knowing your experience with risedronate as it is an agent in my tool box also, for the future. What's the dosage and frequency that you've used so far? What's your CTX at end of evenity, and the readings after you took risedronate? I read one of the papers regarding risedronate in which CTX of subjects treated with risedronate had decreased from an avg 800 to mid 100s by 4 weeks. Maybe the dose and frequency would make a difference? It will be nice to see how yours compare. Thanks

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Replies to "Hi @awfultruth i'm interested in knowing your experience with risedronate as it is an agent in..."

@mayblin, Good to hear from you. I have not got my use of Risedronate as an interim med in between two rounds of Evenity worked out. Hopefully I am not losing bone but clearly once monthly Risedronate is not holding my CTX down to where I'm guessing it should be.
Here is what's been happening:

Date Osteo Med Testing

09-30-24 Last Evenity shot
10-31-24 264 pg/ml CTX
11-16-24 Risedronate 1
12-13-24 371 pg/ml
12-16-24 Risedronate 2
12-30-24 Risedronate 3
01-14-25 169 pg/ml
01-19-25 Risedronate 4
02-17-25 396 pg/mL
02-21-25 Risedronate 5

My current plan is to just start taking the monthly Risedronate dose every 2 weeks. You can see that I did that with Risedronate dose 3 and it brought my CTX down into a desirable range right away. Otherwise it has not been able to keep the CTX score down.
I've checked the early Risedronate studies and there was no evidence of any side effect issues with increasing the dosage up to 200mg a month. I will be taking 300mg a month in 2 divided doses. There was no attempt to study a higher amount for osteoporosis. A higher amount was taken short term in studies to help Paiget's disease and there were no significant issues with 30mg a day for up to 3 months and for a few patients nearly 6 months. I'm judging from these studies that two 150mg doses is not risky and should get my CTX down to a better level. I'm not having any side effects worth mentioning.

Any thoughts or comments that you might have would be appreciated. Hope you are doing well.