@2011panc
I asked the same question. I think the reasons were all different. As we became more familiar with the addictiveness of Effexor, we wanted to get off even more.
Reasons have varied from weight gain to physiological affects to psychological affects,, etc.
For me, it is the large dose I am taking, the head fog, forgetfulness and weight gain to name a few of my reason.
It is NOT mu intention to come off 100%, but down to a 'reasonable ' amount. I was taking 300mg (2-75mg in the morning and at night). At one point it was probably an appropriare dose, but not now.
Hope this answered your question...
Ronnie (GRANDMAr)

@2011panc Some us who were taking Effexor simply don't need it any more (I was on it for hot flashes and those days are passed); some folks have side effects they can no longer tolerate (high blood pressure, vision changes, impotence, digestion issues, etc.); some are young women who want to get pregnant, or are (it may cause birth defects); some find Effexor is no longer working for their mental issues; and some are thrown off the drug by loss of insurance, or can't find a doctor to renew their prescriptions.

Good morning @2011panc- I was originally put on Effexor for menopausal symptoms. They were pretty bad- hot flashes, depression- the whole gamut. Years later (I forget how many) it stopped working and I became depressed, again. I had to get off of it.