Please meet with your doctors and contact the pharmaceutical company. I also had horrid 1st side effects - worst I’ve ever experienced but short in duration. I was not prepared because I was neglected! I also shouldn’t done it so close to a double cervical surgery! However after doing the research it’s supposed to be a one time event, which doesn’t repeat itself. Also, I will prepare by drinking water and taking NSAIDs before the infusion. Also, they can do less of an infusion. I’m highly drug sensitive. When things like these happen the way I look at it is my body wrapped up its immune system to do the work. The medicine was asking it to do. In other words, I really needed that medicine. I’ve had this happen with the shingles vaccine as well as the hepatitis C protocol. All three times I thought I was gonna die. After the medicine kills or handles what is lying dormant in my body subsequent injections are handled with ease. That is my experience. I want to encourage you to speak with your doctors, look at adjustments to the infusion And look at the big picture. It’s possible your body is really tired because it’s doing the work to make your bones better and it’s doing it in the places where it’s needed most. If you take that approach then maybe it’s worthwhile but ask your doctors for sure because they can certainly adjust the medication dose!