Evenity injection site pain

Posted by neesie0159 @neesie0159, Oct 8, 2023

Last week I had my 3rd Evenity injections. The MA told me with the first ones that they don’t cause sore arms because they’re given subcutaneous instead of IM. I had them in the morning, by evening my arms were very painful and that lasted into the next day. When I called the rheumatology office for advice I was told this never happens. Right. Same experience the second shots, though slightly less pain. Last week I had a different MA give the injections and mentioned the arm pain, she said that shouldn’t happen. Very minimal pain that time until late afternoon, then I was strapping ice packs to my arms.
Has anyone else had injection site pain?

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@normahorn

I think most of us know the difference between discomfort and PAIN.

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I agree. With my 1st of injections, I had pain in my arms. I couldn't bear them to touch my sheets, so I couldn't sleep in bed. I had to sleep in a recliner with my arms across my chest. However, for me the 2nd and 3rd set of injections I had in my abdomen with minimal discomfort. What a difference--for me. Just sharing my experience in case it might help someone else.

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@normahorn

I think most of us know the difference between discomfort and PAIN.

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Agreed, this went well beyond discomfort.

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@vrgarden

I agree. With my 1st of injections, I had pain in my arms. I couldn't bear them to touch my sheets, so I couldn't sleep in bed. I had to sleep in a recliner with my arms across my chest. However, for me the 2nd and 3rd set of injections I had in my abdomen with minimal discomfort. What a difference--for me. Just sharing my experience in case it might help someone else.

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Thanks, I appreciate this. My only concern is that getting them in a different location will just cause the same amount of pain in that spot. I’ll definitely consider asking for them in the abdomen though.

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@neesie0159

Thanks, I appreciate this. My only concern is that getting them in a different location will just cause the same amount of pain in that spot. I’ll definitely consider asking for them in the abdomen though.

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I had the same concern, but took the chance. Fortunately, it turned out to be a good decision for me. If you decide to try the abdomen, let us know how it turns out for you. Best wishes!!!

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Had my first Evenity shots yesterday. The left arm injection was not a problem. The right arm injection burned somewhat and was uncomfortable. Today my left arm site has just a little redness, about an inch in diameter. My right arm injection site is hot to the touch, has a lump in it, and has redness about 1.75 inches in diameter. Go figure.

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@thesandpiper

Had my first Evenity shots yesterday. The left arm injection was not a problem. The right arm injection burned somewhat and was uncomfortable. Today my left arm site has just a little redness, about an inch in diameter. My right arm injection site is hot to the touch, has a lump in it, and has redness about 1.75 inches in diameter. Go figure.

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I've posted this before, but saw your post and wanted to share. I received my 1st set of Evenity injections in my arms and they were extremely sore for several days (much better after a week). I decided to have my 2nd set in my abdomen--very little discomfort! It was so much better, I had sets 3-12 in my abdomen also. I was able to wear jeans and waisted clothes with no discomfort at all. No guarantee, but it's worth a try the next time. Let us know how it goes.

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I think I am five months into my monthly injections of Evenity. The first time I had stomach shots with no problems. I get a different stomach shot weekly during infusions at my cancer clinic (and had previously had Xgeva and also Prolia stomach shots for several years). The second time I got a Evenity shots they did them in the backs of my arms. That night I reached for something and realized I had a golf ball sized lump behind my right arm and a smaller one behind my left arm. It scared me because I forgot about the shots and after a failed transplant, I don't have an immune system and am open for every other kind of cancer. When I realized it was just the shot causing the lumps I had a good laugh. 😅 I had a shot behind each arm again today and this time I have a huge lump and swelling behind my left arm and a much smaller lump behind my right arm. When she gave me the shots I yelped out loud. That was a first but it really did sting. I mentioned what the RN said at the cancer clinic, that if they give the shots slowly it doesn't hurt much if at all. One shot specifically says to take several minutes to administer the shot. I don't know if that is the case with Evenity or not, but next time I will opt for my stomach with one on each side instead of using my arms. I have never requested using my arms so I am not sure why they seem to like that better ? Has anyone else had a pretty good sized lump ? I think it may just be the speed of the shot not allowing the shot liquid to be absorbed into the tissue. Last time I had the lump experience it took about a week for the lump to go down and disappear.

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I only had a lump twice in the yearly series when it was given too quickly and too close together. The shots should be room temperature and at least two inches apart, but occasionally you can get a nurse who is in a hurry, unfortunately. I always got both of mine in the same arm, and alternated arms each month. Usually there was minimal soreness and at least one arm is unaffected. I also took an antihistamine the night before the shots, the day of, and for at least the next day. That helps with inflammation. Good luck. Just ask your nurse to slow them down.

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@spunkyspinster

I think I am five months into my monthly injections of Evenity. The first time I had stomach shots with no problems. I get a different stomach shot weekly during infusions at my cancer clinic (and had previously had Xgeva and also Prolia stomach shots for several years). The second time I got a Evenity shots they did them in the backs of my arms. That night I reached for something and realized I had a golf ball sized lump behind my right arm and a smaller one behind my left arm. It scared me because I forgot about the shots and after a failed transplant, I don't have an immune system and am open for every other kind of cancer. When I realized it was just the shot causing the lumps I had a good laugh. 😅 I had a shot behind each arm again today and this time I have a huge lump and swelling behind my left arm and a much smaller lump behind my right arm. When she gave me the shots I yelped out loud. That was a first but it really did sting. I mentioned what the RN said at the cancer clinic, that if they give the shots slowly it doesn't hurt much if at all. One shot specifically says to take several minutes to administer the shot. I don't know if that is the case with Evenity or not, but next time I will opt for my stomach with one on each side instead of using my arms. I have never requested using my arms so I am not sure why they seem to like that better ? Has anyone else had a pretty good sized lump ? I think it may just be the speed of the shot not allowing the shot liquid to be absorbed into the tissue. Last time I had the lump experience it took about a week for the lump to go down and disappear.

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I had bruises and smallish lumps until there was a substitute nurse and I had none. The difference was she did the injections very, very slowly. I told the other regular nurse and that is how she did them and it was less painful afterwards. I find stomach better, just once I had big time bruising. She said she may have done the injection a little out of the area that they should be in. I find it is best to have the injection done not in line with the waistband of pants. She also lets the Evenity warm to room temperature.

Good luck!

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Thank you. I told the person about doing it slower and the difference it makes. Two seconds later she just plunged the entire shot into my back arm area within a split second. This was a new person I hadn't seen before. I did read the part about not having the injection done within 2 inches of your belly button. Also mentioned that at my cancer infusions the following day since only one person there goes slowly and I wondered if that stomach shot has a distance requirement too ? It wasn't the greatest day as it took three different IV efforts to get the bags flowing, one in each wrist area and one in the crook of my left arm. Five in two days was a lot for my arms. My stomach shot there is weekly following all the bags of IV fluids. Just hours of endless fun. Thanks for saying what I felt to be true. I genuinely appreciated your feedback and suggestions.

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