@cwis I was on just 25mg for 18 years. Tapered off slowly and did fine for 6.5 weeks--then, kerbluey! That's when my body figured out it didn't have any more Effexor stored in nooks and crannies. At that point, it was too late to go back on any dose. It's been eight+ months since my last dose and although good days are outnumbering the bad, I'm still taking supplements to feel "normal"--Effexor is powerful stuff and if you're one of the ones to experience withdrawal symptoms, it can take a loooong time to get over.