@cwis Usually the point is so that you don't suffer unnecessarily. You don't say how long you've been on Effexor, or how long you've been tapering, nor how long at 1/4 of 37.5mg. Are you in a big hurry (no refills on prescription, insurance running out, etc.)? Why not stay here until you don't have any symptoms (the vertigo, diarrhea and nausea) and then go to 1/2 of the 1/4 37.5mg for a few weeks, then stop? Slow and steady wins the race.