I was on Anastrozole for only a month & my BP (already on 2 BP pills) was climbing fast. So the Doc said, let's switch to Letrozole. My BP still inched up slowly over the next 3 months, which made me worry. Then I began to have big night BP spikes up to 180/ & 190/ some nights; I started a 3rd BP drug. By the 4th month it was happening every night. After a trip to the ER again, I told my Doc I was going off the Letrozole. So now I have developed "labile hypertension," which annoys me. The Doc switched me to a different type of hormone therapy called Fulvestrant, which works differently, a "hormone antagonist," delivered as a shot in your bum. Hoping for shrinkage of the tumor. She wants me to add a pill to that called Verzenio, but I'm hoping to wait until fall to add that....I told her I want to enjoy my summer and gardening and not feel too exhausted. So there are 2nd level options if the Aromatase inhibitors don't work for a person.
Wishing you the best in your decisions.