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Not sure what to do? ANA negative but RNP repeatedly high
Autoimmune Diseases | Last Active: Mar 18 1:01pm | Replies (17)Comment receiving replies
Did you figure this out yet? I have all the exact same symptoms, including a negative ANA with elevated RNP antibodies. I also have intracranial hypertension and the feeling on top of my scalp has evolved into what seems to be very similar to a very deep fungal infection/kerion, potentially dissecting cellulitis of the scalp. Also atypical ANCA, high CRP. Waiting for rheumatology, but research is leading towards MCTD or lupus. Curious if you got anywhere.
Replies to "Did you figure this out yet? I have all the exact same symptoms, including a negative..."
No answers yet and no changes in symptoms - they seem to wax and wane a bit. No idea what makes things better or worse. I’m waiting for a skin biopsy to look for small fiber neuropathy. I’m sorry you’re going through this too!
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With atypical ANCA, high CRP and your scalp symptoms, I would recommend researching vasculitis. There are many different types, rare autoimmune diseases and a special clinic like your local university rheumatology clinic or Mayo, etc would be appropriate. I have 7 AI disorders, vasculitis being the latest to develop and because it’s rare, you need a special rheumatologist who deals with it and understands it. A dermatologist could do a skin biopsy if you have a rash or lesions on your scalp. If it’s vasculitis, topical steroids or oral Prednisone may help. Good luck and keep us posted on your progress!