Hi. Hard for me to remember the details. I have been on it for about two and half years. It took several months before I started to get any relief because I started on a very low does (0.1 mg/day) and very slowly worked up to my current dose of 3mg/day. I dont have much GI upset or dizziness, but got strong improvements in fatigue and brain fog. When I started I could not use a computer because of photophobia and headaches. The photophobia completely went away and the headaches more than 50% reduced. Best wishes to you.