I haven’t posted in quite awhile, and my situation may be a little different. My doctor and I wanted me to get off Effexor (37.5mg) which I’ve been taking for two decades. Yes, it’s a lighter dose but I am extremely sensitive to all antidepressants I’ve taken (Paxil, Prozac, Zoloft, Lexipro). It was suggested I start taking Wellbutrin (100 mg) along with Effexor, but to take the Effexor every other day. That’s what I did and I was fine. I was on that regimen for two months and decided to go an extra day without Effexor. Yes I had brain zaps but they were tolerable. The problem was I got virtually no sleep when I retired for the night. Back to every other day for another couple of months. Last week (just before X-mas) I did it again , but this time I stretched it out further and as of today, it’s been five days since my last Effexor. Lots of zaps but no negative mood changes and I slept nine hours last night. The Wellbutrin is working so far and I intend to continue taking it, even when I’m off Effexor. Assuming I can at last “defeat” Effexor, I may attempt to eliminate Wellbutrin at some point. All attempts in the past to rid myself of antidepressants have been futile. The goal now is to get Effexor out of my life——-one step at a time.