So I'm one of those that have side effects to many drugs. I decided to try supplements before trying some of these meds with all the side effects. I did try a smaller dose of alendronate (sp) and had side effects. Was given sample of another drug and had one dose (the goal was to take one a month to see what reactions I would have) and stomach issues. The pharmacist said I would see if I really react after the 2nd dose but since I saw the Dexascan, I chose to stick with the supplements. Been taking them for about 8 months and my last dexascan showed a 12% improvement. Went to Mayo in January for their input. The doctors and the facilities were absolutely the BEST. Can't say enough good about this place. That being said, I did go ahead and get the Dexascan that was scheduled before I saw them. I sent results to Mayo for doctor review. She was still a hesitant to just rely on the improvement. Here is what I know for sure. I'm not having all the muscle spams I was having. i don't have the pain in my bones I was feeling. I believe it is working. I do need to put an exercise program back into place to build muscles back but I'm hopeful. Just thought I'd share.