I was on it as an adjunct to Wellbutrin and Cymbalta. It did lift my depression but I had a tremor so bad that strangers would ask me if I had Parkinson’s disease. Then onto Remeron which increased my disabling migraines worse, then onto Seroquel. I really had great benefits from Seroquel and specifically for chronic insomnia as well as my depression (of 41 years). However, I developed Tardive Dyskinesia, (strange mouth movements and toe movements) which I didn’t even realize I had until I accidentally recorded myself on a Zoom call. I was horrified by watching myself. Got off of it and thought the Tardive Dyskinesia was permanent, which it can be, however after being off of it for a year and a half have finally subsided. The world of pharmacology for treating resistant depression is crazy. And although the group of medications like Abilify, called antipsychotics can be very beneficial but to me the side effects were not worth it. I’m on a complicated pharmaceutical regiment for depression, anxiety, insomnia and chronic severe migraines. But finally after searching for 41 years I found hope. Finding a really good psychiatrist with an excellent pharmacology background has been the key for me. Best of luck to you in your journey. As they used to say as far as medications for depression and anxiety, they’ve come a long way Baby.