I, too, have tortuous colon. I’ve finally found what works for me. Constipation is my enemy. What’s working for me is fiber capsules, Miralax, and stool softener, plus a daily treat of raw carrots and celery. I also manipulate my colon by massaging my belly, to help the stool to pass. I take too many meds already and don’t want to add others if I don’t have to.