I thought I had responded to this comment two days ago but can't find it. I will try again:

Thank you for your worthwhile suggestions. I certainly like your thought that GGOs might not be related to the cancer; I requested a strong course of antibiotics early in the process to see if it would have any effect on the lesions (it didn’t). All of the doctors so far (one surgeon, three oncologists, two pulmonologists, and a tumor board), based on reports and their experience, have assessed the GGOs as cancerous –certainly enough of the GGOs to work with that as an assumption.

I know that Tagrisso can protect the brain from metastases. Multifocal lung cancer, however, has a reduced risk for metastases, especially for GGO lesions. Multifocal lung cancer, again especially with GGOs, can also indicate a better prognosis than more traditional types of cancer, for example, an average 5-year survival of 85% in multifocal GG/L tumors (which were mostly part-solid) in one study. I used to receive brain MRIs with my every-three month CT scans, none of which showed brain metastases.

For me, I see the change to solidity as a wild card, especially with all of the lesions becoming solid. I don’t believe there is a standard-of-care answer for me but I had hoped to find others who had a similar experience with GGOs becoming solid after starting Tagrisso and to learn of their treatment plans.

I do feel OK, aside from the effects of losing 40% of lung capacity and side effects from Tagrisso (I am taking the lower 40 mg. dose to help manage side effects).