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I need to as a question. I have been on Effexor 37.5 for about 4 months. I also take elavil 50 mg at night and klonopin 0.5 at night. I don't feel the effexor is working or is anything because I remain depressed. I know this is a very difficult time for me as this is the first Christmas without my husband and nearing the 1st year of his death which is Jan. 7, 2018. However, for the past week or so I have really been feeling ill. I cannot sleep through the night, body hurts along with head pain when I do lay in bed. My body hurts all over, weak, unsteady gait. I also have fibermyalgia and osteoarthritis and take percocet right now 3 time a day and CBD oil. I am not sure if I am having a reaction to the effexor. Would I have this severe reaction after all this time? I will call the doctor tomorrow I think as I cannot handle much more pain. I don't feel these feelings are all depression, but I just don't know anything right now.

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Replies to "I need to as a question. I have been on Effexor 37.5 for about 4 months...."

Hi there,
Welcome to Connect.
Your sleep, headache & body aches are side effects of Elavil. Are your pains mostly in your joints or general body aches? Why were you given Elavil. You say you have weakness and unsteady gait, body hurts all over, those are all side effects of Elavil, ask your doctor. Antidepressants have potential serious (especially) long term consequences, some irreversible and permanent. There are often other ways of helping the symptoms of depression even after starting medication. I understand Fibromyalgia and Arthritis can be intensely painful. You might consider getting off the Effexor, Klonopin & Elavil and recheck your symptoms.
Good luck,

@summertime4 I'm not sure about the other meds, but for treating depression, 37.5mg is very low. That's what I started at since I'm sensitive to meds. A therapeutic dose (strong enough to work) is usually at least 75mg, according to my old psychiatrist and iirc. It is possible that you actually need to increase the dose before deciding if it works or not. And another 6-8 weeks to let it take full effect.

You should ask a pharmacy about interactions with the CBD oil. I remember my psychiatrist advising me not to use marijuana (which I can't even stand being used near me so no problem there) with venlafaxine. I'm not sure if it is because it interacts badly or just isn't a good idea to mix it.