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Which ADT medication is best?

Posted by Beachcomber20 @itsaquarter23, Feb 12 11:28am

Which ADT medication is best? My medical oncologist first suggested six months of Lupron, but she was fine with Orgovyx when I mentioned that prostate patients seem to prefer it because Orgovyx wears off quickly when you stop taking the pills. But my radiation oncologist says I should do six months of Lupron injections, because the studies showing a benefit from ADT using Lupron. And he argued that some of that benefit may have come from the fact that Lupon lingers in your system and thus continues to help for a few more months after you stop taking it. For those of you who've been on ADT, I'd appreciate your thoughts about which way I should go—Orgovyx or Lupron. And if I do Lupron, do I need to take additional medications with them to deal with side effects? The medical oncologist said no additional meds would be necessary if I took Orgovyx.

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heavyphil | @heavyphil | 6 days ago
In reply to @ptjeep "I would avoid Lupron if you can, I was on Lupron for 12 months, and I've..." + (show)
@ptjeep

I would avoid Lupron if you can, I was on Lupron for 12 months, and I've had all of the side effects, I've been off Lupron for 13 months and I still have all the side effects, and my depression only seems to get worse. What angers me the most is that once the Dr's. castrate you and have you in remission they really don't seem to care how you deal with all the loss that is going to be with you for the rest of your life. Yes they may have extended your life but with no libido, and I mean none, well it's one heck of a trade off.
From what I've seen Orgovyx would be a better option if you can afford it. I could not.

Very Best Regards,

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Hey jeep, that’s a long time to be off ADT with no relief of symptoms. I can understand your urologist’s reluctance at giving you T.
Some men have their emotional wiring severely impacted by ADT and it doesn’t just bounce back once the meds cease. You really should look into an RX for Wellbutrin to help with your depression. There have been MANY comments on this forum about how it helped with depression and other emotions. Search the topics and you’ll find it.
Remember, hormones and emotions are a very complicated issue. PMS and post partum syndrome in women are classic examples of depression, anxiety and mood swings caused by a lack of a hormone or an imbalance in two of them. Men are no different - just not as widely studied since we don’t have menstrual cycles or give birth.
But your hormonal upset caused by ADT has definitely short circuited your normal brain chemical balance. Please feel NO shame or reluctance in seeking help. You probably need a jump start at the very least and how you progress will determine future need for the meds. It’s no different than a diabetic needing insulin! Best
Phil

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