PB50 I "discovered" you this morn while looking for the new alternatives to prilosec. Wow. We've got stuff in common. I've suffered from debilitating diarrhea off and on for years - initially treated as antibiotic induced colitis - you know, where you miss events, don't travel, don't stay overnight with anyone... your life as you knew it is gone. The gastro was disinterested - possibly related to my being 70? Tests showed I didn't have c-dif, but was lactose intolerant. I read enough to think it could possibly be related to the prilosec. I stopped it, tried famotidine, but went back to prilosec. I had heard about microscopic colitis. Then my wonderful family practitioner (who actually did listen and talk with me) asked me to consider a round of Xifaxan- sooo expensive, but I was willing to try anything. It helped - a lot. Then at Christmas this year I became sick with a sore throat that wouldn't go away and cough that rattled the house while trying to sleep. Doc was very hesitant to put me on antibiotics, but we decided to go for it...a round of antibiotics AND 10 days of a steroid. Plan was to stop everything if it set the diarrhea off. 3rd day, here it came, but I decided to try and weather it. Took Imodium once and finished the meds. Everything cleared up with my stomach. I can eat anything and everything now. Microscopic colitis? I'll talk to my doctor about that now. Anyway! I'm going to try and wean off the prilosec again. You've given me so much to think about. I believe your info is going to help me. Good luck with all of your issues!