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@mayoconnectuser1

I suspect most of your father's plaque build up from from earlier in life - and, the statins probably did their job by reducing plaque, and by calcifying already present plaque.

While I know you feel certain about ratios, I would urge you to get your cholesterol under control with injectables.

And to Vascepa - jury still out on full effects, but its core purpose is usually to reduce LDL.

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Replies to "I suspect most of your father's plaque build up from from earlier in life - and,..."

You misunderstand. I don't know what your knowledge base and experience is. But he CAD. (I think I wrote all this in the hormone section or a heart disease comment today. We have familial CAD. The guy swam 3 times a week and we came from a produce business family. Ate a Mediterranean diet. No smoking or alcohol. rare were treats in our house. Polyunsaturated oil only. Rare processed food. We ate fresh only. Yet at 58 he had a heart attack which required a triple heart bypass. The statins did nothing to reduce the angioplasties and stints in between the next QUADRUPLE (at 72) and TRIPLE bypass surgery at 80. Nothing to stem the tide of TIA stroke and major hemorrhagic stroke at 87. What they did do early in life was margarine. It probably was the transfats that was unknown to them. My cholesterol IS under control. And I DO injectibles. I am on LEVQIO. But, that seems to not be changing my LPa score yet. But I started BHRT again.
However your statement is not accepting the reality: That the arteries CLOSED AGAIN. plaque continue to grow NEW into the okay parts of the arteries. They were newly acquired deposits. They removed the old blocked vessels. So as life continued - he acquired NEW blockages. He did all the right things and took all the right medications to keep the blood from clotting and clogging, plus doctor recommended vitamin D. He was a very active man until maybe the heart bypass at 80.
The Vascepa did NOT lower my LDL, did not improve my ratios, did not lower my cholesterol. There is a big difference between an uninformed layperson and someone who has been studying this for 4 decades. I work closely with my doctors. I worked closely with my dad's cardiologist. I am at UCSD Healthcare. I have some of the finest teaching doctors in the world.
Statins work great for some and for some, they get GREAT results with addition of injectables. which work on a different mechanism. Interfering with the PCSK9 protein. I think you are a bit misinformed about Cholesterol and the role it plays in some plaque buildup and those with the disease of atherosclerosis. https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/arteriosclerosis#:~:text=What%20Is%20Arteriosclerosis%3F,diabetes%20and%20certain%20genetic%20influences.
CAD: https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/coronary-artery-disease
Also, you seem to think we don't have our numbers in line. My LDL has been cut by a 1/3 from 138 to 82 so I must be doing something right. HDL is about 72. My non-HDL is 114 (optimal) but I want my triglycerides down from 160 to 111, which would make me happy.
My numbers are good. Over 10 years they have all dropped dramatically. It was the fish - the real fish that helped the most! And taking some weight off.