I recently switched from Advair to Breyna 160mcg/4.5mcg inhaler. I also switched from Spiriva Handihaler to Spiriva Respimat, as it was becoming increasingly difficult for me to inhale the medication via the Handihaler.

The Spiriva inhaler is so easy to use; it has never misfired. It is comfortable to grip and the "trigger" button to release the medication is easy to press down. I know each time I'm receiving a dose.

On the other hand, The Breyna inhaler is problematic for me to handle: the unit is small, difficult to grip, and the button is difficult to push down. I find I have to use both forefingers with one on top of the other to push it down. Even then, there are times I don't think I'm getting any medication. The button has to be pushed down "just right" in order to release the medication.

I've never had this issue with any of my other maintenance and rescue inhalers.

As for storage when not in use, this is from Breyna's website:

"Store BREYNA at room temperature between 68°F to 77°F (20°C to 25°C).
-------> Store BREYNA with the mouthpiece down. < --------
The contents of your BREYNA canister are under pressure. Do not puncture or throw the canister into a fire or incinerator. Do not use or store it near heat or open flame. Storage above 120ºF may cause the canister to burst.
Throw away BREYNA when the counter reaches zero (“0”) or 3 months after you take BREYNA out of its foil pouch, whichever comes first.
Keep BREYNA and all medicines out of the reach of children.