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@dlgbb

I just had a total hysterectomy with removal of fallopian tubes, ovaries, and pelvis and aortic lymph node testing. All came back as well as I could hope, other than substantial lymphovascular invasion. Diagnosis was grade 3 endometrial endometrioid carcinoma. I did have genetic testing done, and it came back with several genetic mutations, including POLE. As the testing showed MSS and very high Tumor Mutation Burden, I am really hoping that immunotherapy may be the only follow up, but I have no idea. I have my surgery follow up in 2 weeks.

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Replies to "I just had a total hysterectomy with removal of fallopian tubes, ovaries, and pelvis and aortic..."

That's great news that your tumor has a POLE mutation and a high mutation burden. It will be interesting to see what follow-up your doctors decide on. Based on the literature, it seems that there's a low chance that your tumor would recur even if they only observe. What are you hoping for?