My husband was on Semaglutide before beginning prednisone and had lost 25 pounds. Enter Steroids, weight back. Still staying on the weight loss injections because we know that he would have gained more and still may. We have been here before without a weight loss drug and the weight gain was significant (40 lbs), so we are staying on both. They have not interfered with each other. But was hoping the weight gain would be slower. Go for it if your doc says it’s okay. Might save you from gaining another 20lbs.