Hi..I was gleason 10, and 80 when the pc was found I got on Orgovyx first, after 2 months on, began 45 radiation sessions. The orgovyx worked well, some side effects (fagique, muscle aches, a few hot flashes) I was told 24 months on the adt. After the 45 radiation treatments my psa was undetectable. I continued the adt for 18 months, and took a break. Hope this helps, and good luck with it all.