I've been on Budesonide non-stop since I was diagnosed with Collagenous Colitis in October, 2023. I have had no discernable side effects and have so far managed to taper down to 3 mg a day. I have a follow-up with my GI in March and will likely try to get down to 3 mg every other day. The side effect I was most concerned about was loss of bone density since I already have Osteopenia. I've been taking supplemental calcium (1500 mg daily) and actually saw my bone density improve on my April, 2024 Dexa scan. Keep in mind that we are all different and react to meds in very different ways. Best bet is to discuss your concerns with your GI doc and monitor for side effects.