Seroquel is a usually a serious drug. I'm not sure, but don't think it is something to go off cold-turkey....it could cause serious mood swings and possibly psychosis....the effexor withdrawal is not pleasant, but rarely dangerous. If you were prescribed both (and had to stop the effexor for the antibiotics - although I've never heard of it being contraindicated ) - I would try to speak with the doctor.....MRSA plus an SNRI plus an atypical antipsychotic is a complicated regimen.