I was on Simvastatin throughout my hormone therapy (Eligard). My cholesterol level was not adversely impacted at all.

That said, I did greatly ramp up resistance training and cardio programs, and also improved my diet prior to, during and after treatments ended. The purpose of ramping up my resistance training routine was to minimize most side-effects of hormone therapy, but that also might have improved my bloodwork results as well. (I had no moodiness, crankiness, etc. Later, I asked my wife about that. She said that she hadn’t noticed any. She said that except for my complaints about mild warm flashes and muscle atrophy, that she wouldn’t have noticed I was getting radiation treatments or on hormone therapy.)

With the increased exercise, cardio, and dietary modifications, not only did I not gain weight, I actually lost 40 lbs. (and 3 waist sizes, and had to buy new clothes that fit better). Most side-effects of hormone therapy can be minimized with resistance training.

With the enhanced exercise program, ADT was no big deal at all; and cholesterol levels were unaffected. Go with it.