1. < Colorectal Cancer

Latest Signatera test went from negative to 1.02

Posted by cjay @cjay, Feb 2, 2024

My 4th Signatera test results just came back, and for the first time since my resection surgery it’s a positive result of 1.02
I have my first CT scan (since my treatment ended) next week.
Trying to stay calm and positive until the scan results come back, but of course that’s difficult.
Does anyone have any experience similar? And what happened after that positive test?
🤞🙏

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darrincag | @darrincag | Feb 12 11:03am
In reply to @reidroberts "After chemo, radiation and surgery, I think I had 6 months of Signatera tests that were..." + (show)
@reidroberts

After chemo, radiation and surgery, I think I had 6 months of Signatera tests that were zero showing no signs of cancer. Then the signatera tests became positive .03, .06, 1.1, 4.2 and up. Scans did not detect any cancer until the 4.2 reading. By the time we did the cryoablation, the Signatera result went to a 15. After the cryoablation I was put back on FOLFOX for 6 rounds. By the 3rd round my Signatera was back to zero. After these 6 rounds they dropped the chemo that causes neuropathy but continued with the other 2 chemo chemicals for another 12 rounds. I have done 4 of these with 8 more to go. The hope is that any residual cells that may try to pop up over a longer term will be killed off with these additional treatments and not become a problem and gone forever. I am on a 2 week Chemo schedule. I don't feel too good after treatments for 4 to 5 days and then start feeling better over that second week. Workwise I do what I can to help out but I am not as directly involved in day to day operations anymore. I have quite a bit of nausea and fatigue for the first week after chemo treatments. Constantly taking the nausea medication helps quite a bit. Hang in there and keep reaching out to people for all the info you can get.

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I got my first +Signatera test this morning. Had a resection last January and 4 rounds of CAPOX into June. My team has sped up my screenings to keep an eye on things. I only just joined the forum, and it’s inspiring to hear all your stories of fighting and staying positive! After two 0’s my test came back today at .13…I’ll continue reaching out and keep you all informed! Good vibes, prayers and thoughts go out to you all!

REPLY
roywalton | @roywalton | Feb 13 5:46am

Are you seeking an MRI of lung and abdomen? S+ recurrence (SR) occurred at median > 8 months (mo) prior to radiographic disease, So don't be surprised if an MRI or CT does not pick up the tumor. Suggest you try to find an ecologist who has experienced dealing with S+ cases. Let us know!

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1 reply
roywalton | @roywalton | Feb 13 5:52am
In reply to @roywalton "Are you seeking an MRI of lung and abdomen? S+ recurrence (SR) occurred at median >..." + (show)
@roywalton

Are you seeking an MRI of lung and abdomen? S+ recurrence (SR) occurred at median > 8 months (mo) prior to radiographic disease, So don't be surprised if an MRI or CT does not pick up the tumor. Suggest you try to find an ecologist who has experienced dealing with S+ cases. Let us know!

Jump to this post

Hi - I just wanted to add this reference to a recent study which shows a correlation between positive signature and recurrence which you may want to share with your doctor
https://ascopubs.org/doi/10.1200/JCO.2025.43.4_suppl.15

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