I understand your worry. I was so (quietly) against ADT. Cholesterol, yes, but the specter of depression scared me the most. But just two months of orgovyx reduced the tumor by almost half. Maybe he won't be on it long and someone will monitor the cholesterol. A small weight gain was unwelcome, but there was only a small rise in LDL. It would be better if the medication didn't have these downsides, but sometimes the advantage is worthwhile. I hope they want him on a short course. He's lucky to have you worrying for him. I would ask about orgovyx( a pill instead of an injection) thought to be more effective with the benefit that it disorders the tumor's dna as well as starving the tumor.