I have not had any side effects, but some people here have. Plenty of discussions about it. Most people do ok, but some have side effects ranging from very mild to worse. By "worse", I don't mean something that is critical and will land you in the emergency room! More like soreness and discomfort.

That said, don't be afraid. First, the medicine only lasts for a few hours. It's not like you are taking an infusion that will affect you for months and there's no going back.

Second, if you do have side effects, they are often mild and go away within a short time.

Third, some people fiddle with the dose. If they can't tolerate the full dose, the Tymlos pen allows you to "click" up to the dose you want. Some have reported better results with a lesser dose. Others start low and gradually increase it according to comfort level.

I was a little apprehensive at first, too, but I've now been doing it for nearly a year and it's like brushing my teeth. I even brought it with me on vacation last summer. It has helped me tremendously.