I found this thread helpful seeing what others have been experiencing and some of the longer term success that many have had. I was diagnosed with adenocarcinoma over a year ago. Luckily I have the EGFR mutation and I've been on Tagrisso for a little over a year now. I also have infusions of pemetrexed and initially carboplatin every three weeks. I saw a slight decrease in tumors at my initial scan and now every scan since than has been stable. My first two months or so of treatment was just Tagrisso. I didn't notice any issues initially but the occasional diarrhea, but nothing too bad. Now I'm pretty tired feeling most of the time but I am guessing that is from the pemetrexed and not the Tagrisso. I'm still able to do all of my hobbies and most of the time when I get moving it gets easier. One issue I've been having is high liver enzymes, they are always above normal and have seen them as high as double the max range, has anyone else had liver enzymes above normal? I worry that I might have caused some damage prior to my diagnosis. I spent a year in agony with horrible headaches from the cancer. Weekly ER visits because of the headaches and they finally found something that worked some of the time(indomethacin) but after taking it for a month I was told it was bad for my liver as much as I was on and for how long. They advised I not take any more indomethacin but as my only relief from unbearable pain I continued. Finally I got a second opinion at Mayo about the headaches and within hours they found the cancer causing the pain with an MRI of my brain. Thankfully, I finally got a second opinion at Mayo in Rochester. Anyways, from what I understand Tagrisso will only last into my early 40s before I need to try something new. Trying to stay optimistic that something will be available when things start going the other way, that's probably the hardest part.