Last I understood, and it still seems to be bitterly true, is that psychiatric medicines are just wildcards.

That is to say,

a) because the brain itself is still largely unknown in all its functions,
B) and because the medicines are largely like a shotgun blast to a whole range of sectors and interactions not understood or even known,

There is no telling what all is actually being affected or the chain reaction/ downstream effects.

I’d say Pharm medicine is a far cry from Thorazine and other jackhammer meds from the past. But, like much of medicine, it’s still a best guess in the most narrow sense with a vast array of unknowns. We are always Guinea pigs.