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I am going to start Alpha Lipoic Acid @600 mg/d to determine...

Neuropathy | Last Active: Feb 11 8:47pm | Replies (16)
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@dieterreuther

During my research of what to take for my polyneuropathy I learned from Dr Emily Splichal’s book Barefoot Strong that it has to be R-ALA instead of regular ALA: “Touted as one of the most powerful anti-oxidants, alpha lipoic acid has been shown to improve microcirculation to peripheral nerves while decreasing oxidative stress. A key point about alpha lipoic acid is that it must be taken in the R-lipoic acid form as the “R” form is the one that is biologically active (vs. “S” form).”

Initially I took it mornings and evening, but to be supportive of my silent reflux I now take the whole dosage in the morning.

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Replies to "During my research of what to take for my polyneuropathy I learned from Dr Emily Splichal’s..."
diannesmcneill | @diannesmcneill | Feb 10 7:02pm

Tell me about your silent reflux. I just got diagnosed with reflux and Barrett’s.

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fatalfflaw | @fatalfflaw | Feb 11 11:55am

I remebered reading that a racemic mix might be better , but I think I originally read it on a 'dot.com' site , so I gave it less credence since they were trying to sell product. But a cursory look provided this input:
" It has been hypothesized that R-ALA would be the most appropriate form of commercial supplement; however, it is prone to polymerization and is absorbed to an even lower extent than racemic-ALA. As a matter of fact, it has been demonstrated that the presence of the S-enantiomer in the racemic mixture prevents the polymerization of R-ALA to some extent, increasing its bioavailability [6]. For this reason, the best nutraceuticals or food supplements available on the market are represented by highly pure forms of food-grade racemic ALA in order to keep the polymer content at a low level ensuring stability over time and optimal absorption. These products are often available in various forms such as fine powder for softgel formulations or ready-to-use granules for tablet preparations."
https://pmc.ncbi.nlm.nih.gov/articles/PMC6723188/#sec7-biomolecules-09-00356

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