I’m 61. I’ve had multiple stress fractures in the same foot over 4-5 years and finally my doctor considered these fragility fractures. My DEXA score is in osteopenia range. I had Reclast a year ago but got the fourth stress injury in May, thus Tymlos was prescribed and insurance approved. The Tymlos is supposed to help my foot as well as other bones seen in DEXA.

I ramped up the dose to six clicks over about 2 weeks because full dose increased my heart rate so much. I still get a fast heart rate but not as intense. I’m experimenting with time of day to take the Tymlos. But— for the past two weeks I’ve had aches in one leg and hip and pretty bad knee knee pain in one knee. Plus rib or shoulder pain (hard to tell origin.). I guess this started once I got to six clicks. I don’t know how to discern if the knee pain is from Tymlos. If the knee pain is caused by Tymlos it defeats the purpose because I need/want to be active and weight bear. My doctor (Stanford) has no suggestions except to say that she thinks Fortreo would be worse. I’m feeling discouraged and trapped. From reading here it sounds like on my own I should 1) stop the Tymlos for 1-2 weeks, then restart and ramp up even slower than I already did. I can deal with aches but not pain and inflammation. Has anyone else had visible swelling of a joint from Tymlos? I would welcome advice and input. I don’t think I can do this for two years if the knee pain is a side effect.