12 years on effexor. Pooped out. Put on 50 MG of desvenlafaxine. The two are alot alike. I took my 150 MG of venlafaxine along with the desvenlafaxine 50 MG for 3 days then STOPPED the venlafaxine completely. Zero withdrawals. Now on 25 desvenlafaxine with zero withdrawals. Not sure after the 25 because I still need something. All this in 3 weeks. Just a thought.