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Vitamin B6: pyridoxine hydrochloride vs. pyridoxal 5’-phosphate?
I had posted this earlier in the midst of a longish thread. As I've not had any responses, I thought I might post it as a topic all its own:
Good morning. Maybe someone following these posts about B6 can help me sort something out. I understand vitamin B6 is available as pyridoxine hydrochloride in multivitamins, vitamin B-complex, and vitamin B6 supplements. My neurologist tells me that pyridoxine hydrochloride in the form of vitamin B6, if taken in excess, can lead to toxicity with its various PN-like symptoms. He assures me, however, that the form of vitamin B6 that I’m taking in EB-N5, which is pyridoxal 5’-phosphate, is essentially different; pyridoxal 5’-phosphate comes with its own dosage guardrails, but not the same toxicity concerns that accompany pyridoxine hydrochloride. Have you met this “two forms of supplemental B6” issue in anything you’ve read or been told? I have found brief mention of it in only a few places. I’d love to get some clarity. –Ray (@ray666)
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Welcome @bluestarborn88, I thought I would share the link for you since new members are not allowed to share links for a short period of time to prevent spammers on Connect.
Whole Food vs Synthetic Vitamins | Vitamin B6 | Dr. J9 Live: https://www.youtube.com/watch?v=JpdWYa-VNsE
Also one of her other videos mentioned this reference:
-- Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8483950/
Do you have neuropathy also?
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1 ReactionHi John,
Thank you so much for sharing the links!
I don't have neuropathy, but have other minor health issues.
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2 ReactionsHello, I have notes I made when researching "critical nutrients for nerve repair" in which I noted this recommendation:
B6 - Pyridoxal-5-Phosphate - 80-100 mg (the active form of vitamin B₆, is a coenzyme in a variety of enzymatic reactions). I believe it was from a doctor online. He said the more expensive forms of the B vitamins were more effective than the cheaper versions usually used in inexpensive multi-vitamins. Hope this helps.
Why supplement when nutritious whole foods are the best source of the vitamins and minerals that we need? So many supplements, as well as vitamins or minerals are removed from foods during the processing faze and then added back in the form of synthetics. Our bodies were not designed to know how to use and sometimes eliminate these fake sources/chemicals. Are you deficient due to what you are or are not eating?
Vitamin B6 is found in many foods, including fish, meat, vegetables, fruits, and nuts.
Fish
Salmon: A rich source of vitamin B6
Tuna: A high-protein food that's also a good source of vitamin B6
Meat
Beef: A good source of vitamin B6, especially beef liver and other organ meats
Poultry: A good source of vitamin B6
Vegetables
Potatoes: A good source of vitamin B6, especially sweet potatoes
Spinach: A good source of vitamin B6
Lentils: A good source of vitamin B6
Fruits
Bananas: A good source of vitamin B6
Other non-citrus fruits: A good source of vitamin B6
Nuts and seeds
Peanuts: A good source of vitamin B6
Other nuts and seeds: A natural alternative to vitamin B6 tablets
Other foods
Avocados: A good plant-based source of vitamin B6
Fortified cereals: A good source of vitamin B6
Chickpeas: A good source of vitamin B6
Eggs: A good source of vitamin B6
Milk: A good source of vitamin B6
Vitamin B6 is important for brain function, metabolism, and the development and maintenance of the central nervous system.