Vitamin B6: pyridoxine hydrochloride vs. pyridoxal 5’-phosphate?

Hi Ray,

You might have already found more info on that.
Just in case : The pyridoxine hydrochloride is the Synthetic Vitamin B6.Synthetic Vitamin B6 – Pyridoxine hydrochloride comes from petroleum ester, hydrochloric acid, and formaldehyde. It isn’t readily absorbed or converted and has been shown to actually inhibit the action of natural B6 in the body. It also has side effects not normally found with natural food sources of this vitamin. It has been found that long-term use of high doses of synthetic Vitamin B6 can cause neurological problems such as tingling and numbness in the hands and feet due to nerve damage caused by an accumulation of unmetabolized molecules from supplements.

Natural sources of vitamin B6 is Pyridoxal 5 phosphate, it's the active form of vitamin B6 refer primarily to food products derived from animal or plant sources which contain active concentrations of this micronutrient including poultry, beef liver, eggs, bananas, avocados and potatoes, red bell pepper (raw), pasilla peppers (dried - from Mexico), leafy greens like spinach and kale, dried shiitake mushrooms, chickpeas, sunflower seeds, pistachio nut.
Foods High In Vitamin B6

Natural forms of vitamin B6 are more likely to retain its bioactive components since they haven’t undergone any chemical processing prior to ingestion.

Dr. Janine talks about whole food vs synthetic vitamins looking specifically at Vitamin B6.

As a new member they didn't let me provide some links that I wanted to post. Might repost this in a few days or so.

Welcome @bluestarborn88, I thought I would share the link for you since new members are not allowed to share links for a short period of time to prevent spammers on Connect.

Whole Food vs Synthetic Vitamins | Vitamin B6 | Dr. J9 Live: https://www.youtube.com/watch?v=JpdWYa-VNsE

Also one of her other videos mentioned this reference:
-- Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8483950/
Do you have neuropathy also?

Howdy!
I take EB N5 as well. I have Sjogrens top of neuropathy. i tested toxic for B 6 (488!)
BUT... I do not think the toxicity was caused by this brand. i wad also taking vitamin gummies and I think the gummies did it????
I DONT KNOW. Someone please help! Neuropathy sucks and I was so stoked to find a product that could help. If I quit all other sources of B 6 eould it be OK to return to taling the EB N5????

Welcome @miacrab, If the EB N5 is helping your neuropathy symptoms and providing some sort of relief, I would keep taking it if it were me but I'm not a doctor. There are many other vitamins and sports drinks that contain a high level of B6 that I would avoid taking. Not sure how much B6 your gummies had but it might be good to find ones without B6.

Have you had a discussion with your doctor on the B6 levels?

Hi thanks for answering. Yes, now I avoid ALL forms of B 6 but not sure if the B 6 in EB N5 is the same? It is called P5P. I believe the Smarty Pants gummies and other supplements have caused the toxicity, However, I was told I would get relief from neuropathy from P5P in the food-medicine called EB N5 (It contains other nutrients)
Thank you for your caring words!

Good morning miacrab (@miacrab)

I'm the fellow who posted the original message way back in 2023. Since then, I've been gathering as much information as a layperson possibly can about the distinction between B6 pyridoxine hydrochloride and B6 pyridoxal phosphate (P5P). I've been doing this because, on the suggestion of my neurologist (who is also a physiatrist), I've been taking EB-N5 –– or, I should say, I had been taking EB-N5, now almost two years' worth. Only last month, this same neurologist asked if I might be willing to switch to a slightly different formulation: EB-M8. I've only started taking EB-M8, so I'm unable to give it a grade: 1 for it's doing me harm, 10 for it's the miracle cure we've all been waiting for. Right now, EB-M8 is a ?. I suspect it'll remain a ? for quite some time. As I written here before, with regard to EB-N5, it, too, remains a ?, but that is to say: it does not appear to have done me any harm. In fact, my PN (chronic idiopathis axonal polyneuropathy, or CIAP), whose chief symptom is poor balance (no pain), does not appear to have worsened in all these months, or if it has, it has worsened only microscopically.

My best wishes to you, miacrab, al to all PNers!
Ray (@ray666)

Good morning miacrab (@miacrab)

I'm the fellow who posted the original message way back in 2023. Since then, I've been gathering as much information as a layperson possibly can about the distinction between B6 pyridoxine hydrochloride and B6 pyridoxal phosphate (P5P). I've been doing this because, on the suggestion of my neurologist (who is also a physiatrist), I've been taking EB-N5 –– or, I should say, I had been taking EB-N5, now almost two years' worth. Only last month, this same neurologist asked if I might be willing to switch to a slightly different formulation: EB-M8. I've only started taking EB-M8, so I'm unable to give it a grade: 1 for it's doing me harm, 10 for it's the miracle cure we've all been waiting for. Right now, EB-M8 is a ?. I suspect it'll remain a ? for quite some time. As I written here before, with regard to EB-N5, it, too, remains a ?, but that is to say: it does not appear to have done me any harm. In fact, my PN (chronic idiopathis axonal polyneuropathy, or CIAP), whose chief symptom is poor balance (no pain), does not appear to have worsened in all these months, or if it has, it has worsened only microscopically.

My best wishes to you, miacrab, al to all PNers!
Ray (@ray666)