RARP Pathology report questions

Posted by albcan @albcan, Feb 1 8:55am

Hi Everyone, first off i would like to say how helpful and comforting this forum is and how much we appreciate everyones feedback sharing of experiences ect it is so nice to see and learn from other peoples experiences. I had my RARP on Dec 24 2024, now my follow up appt is Fen 24 2025 so in a few weeks, we had an initial conversation on the phone to review the pathology report but wasn't detailed about next steps ect and we are just waiting unti our next appoint but was wondering about other peoples experience or knoledge of this report.

To set the stage prior to sugery there were multiple lymph nodes "lit up" based on the PET scan but only one that was removed was cancerous so I assume more cancerous ones are left behind, prior to the surgery it was a gleason 8 but now its a 7. The other thing it mentions is the bladder neck and margins which seems to say that those are still cancerous, none of this is a surprise or freaking us out just trying to get a handle on the potential next steps ie hormone therapy radition ect to be prepared and do research on options. The other issue is durring the PET scan there was an area of concern in the thyroid which weve since had confirmation that it is cancerous also so not sure about tretments for both or all areas at the same time ect so any experience or feedback would be greatly appreciated, here are the report highlights. Thanks Again! Al

FINAL DIAGNOSIS:
A) Lymph node, left pelvic, excision: A single (1/11) lymph node involved by metastatic prostate carcinoma. B) Lymph node, right pelvic, excision: Eight lymph nodes are negative for metastatic carcinoma (0/8).
C) Prostate, prostatectomy: Prostatic adenocarcinoma, Gleason score 4+3=7 with a tertiary pattern 5. Extraprostatic extension is present and surgical resection margins are focally involved by tumor. See synoptic. JTL/blb
=====
SYNOPTIC REPORT:
CASE SUMMARY: (PROSTATE GLAND: Radical Prostatectomy) Standard(s): AJCC-UICC 8
SPECIMEN
Procedure: Radical prostatectomy
Histologic Type: Acinar adenocarcinoma, conventional (usual) Histologic Grade
Grade Group and Gleason Score Grade Group
Grade Group 3 (Gleason Score 4+3=7) Minor Tertiary Pattern 5 (less than 5%):
Present
Intraductal Carcinoma (IDC): Not identified Cribriform Glands: Present
Treatment Effect: No known presurgical therapy Tumor Quantitation
Greatest Dimension of Dominant Nodule: 18 mm Extraprostatic Extension: Present, focal
Urinary Bladder Neck Invasion: Not identified Seminal Vesicle Invasion: Not identified
Lymphatic and / or Vascular Invasion: Present
Margin Status
Invasive carcinoma present at margin
Linear length of margin(s) involved: Three foci, less than 1 mm each Margin(s) involved: Left posterior
REGIONAL LYMPH NODES
Regional Lymph Nodes Status Regional Lymph Nodes Present
Tumor Present in Regional Lymph Node(s) Number of Lymph Nodes with Tumor: 1 Number of Lymph Nodes Examined: 19
DISTANT METASTASIS
Distant Metastasis. Distant Site(s) Involved: Not applicable
pTNM Classification (AJCC, 8th edition)
Modified Classification: Not applicable
pT Category: pT3a: Extraprostatic extension or microscopic invasion of bladder neck
T Suffix: Not applicable
pN Category: pN1: Metastasis in regional nodes
pM Category: Not applicable - pM cannot be determined from the submitted specimen(s)
Representative Tumor Block: C10, C16, C18
Comment: Select slides seen in consultation with Dr. Jordan Reynolds.
The synoptic report incorporates information from all relevant surgical material and includes all required data elements of the current CAP Cancer Protocol.

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Well, my first thought is given that pathology report, why the heck did they even do surgery...but as I often say, learn from the past...

I would expect you have choices, some more likely than others.

Doublet therapy
Triplet therapy.

The former is an ADT+ ARI
The latter is ADT+ ARI+Chemotherapy.

There are choices to be made within those choices, which ADT, which ARI, whether to include radiation, how long will the treatment be.

A high risk cancer may answer which course of action you choose.

I am high risk. GS8, GG4, PSADT and PSA, only 18 months to BCR after surgery so I tend to be aggressive on my treatment choices.

Here I am 11 years since my diagnosis, done treatment four times, on treatment three years, off eight..

Kevin

REPLY

Hi Kevin, the way it was explained to us is this was the most aggressive route by doing the surgery first and then seeing where we stood, we did know that it was in the lymph nodes and metastatic prior to surgery but this was the best path forward.

I didn’t realize there were two separate categories you mention ADT and ARI I just had it as “hormone therapy” so thanks for this we will do research on the two so we can have a more informed conversation at our follow up in a few weeks.

From what we understand mine is an aggressive cancer also so we want to take an aggressive approach.

I also appreciate your comment about your journey so far re 11 years in and on treatment four times for three years and off treatment for eight, seems like a good trade off considering where we all are with this disease.

Thanks Again for this information I’m sure we’ll have more questions after our next visit about the choices we need to make going forward.

Have a Great Day

Al

REPLY
@albcan

Hi Kevin, the way it was explained to us is this was the most aggressive route by doing the surgery first and then seeing where we stood, we did know that it was in the lymph nodes and metastatic prior to surgery but this was the best path forward.

I didn’t realize there were two separate categories you mention ADT and ARI I just had it as “hormone therapy” so thanks for this we will do research on the two so we can have a more informed conversation at our follow up in a few weeks.

From what we understand mine is an aggressive cancer also so we want to take an aggressive approach.

I also appreciate your comment about your journey so far re 11 years in and on treatment four times for three years and off treatment for eight, seems like a good trade off considering where we all are with this disease.

Thanks Again for this information I’m sure we’ll have more questions after our next visit about the choices we need to make going forward.

Have a Great Day

Al

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