I was on 300 mg for years but when i started to have problems w my kidneys it was reduced to 225 mg. I have a new MD as of 2 yrs ago. We discussed reducing it more. I spoke w a pharmacist who suggested reducing by 37.5 mg every 2 weeks. I'm taking 187.5 mg now. Went back up for a couple of weeks bc of depression but it was re to infection. Will b going down to 150 mg next week. Some nausea, tremor but better sleep. Do not go cold turkey. It can kill u.